Increased MALAT1 expression predicts poor prognosis in esophageal cancer patients - 21/10/16
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Abstract |
Aim |
This study was designed to determine the expression of metastasis associated lung adenocarcinoma transcript 1 ( MALAT1 ) in patients with esophageal cancer (EC). In addition, we attempted to seek the prognostic value of MALAT1 in EC based on its expression.
Methods |
The expression of MALAT1 in EC tissues and cell lines were measured by quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR). The association between MALAT1 expression and the clinical characteristics was analyzed using Chi-square test. Kaplan-Meier survival curves were plotted to describe the overall survival of EC patients with different expression of MALAT1 . Cox regression analysis was per formed to evaluate the prognostic value of MALAT1 for EC patients.
Results |
Expression levels of MALAT1 were significantly higher in EC tissues and cells than the controls ( P < 0.05). MALAT1 expression was tightly related to lymphatic invasion ( P = 0.018), distant metastasis ( P = 0.033) and tumor differentiation ( P = 0.025), but shared no association with age, gender and tumor location ( P > 0.05). In addition, patients with high MALAT1 expression had a shorter overall survival than those with low MALAT1 ( P < 0.001). The results of Cox analysis shown that MALAT1 was significantly linked with the prognosis of EC patients (HR = 6.638; P = 0.000; 95% CI = 2.948-14.947).
Conclusion |
Taken together, the expression of MALAT1 could be a predictor for prognosis of EC patients.
Le texte complet de cet article est disponible en PDF.Keywords : MALAT1, LncRNA, Esophageal cancer, Prognosis, Overall survival
Plan
Vol 83
P. 8-13 - octobre 2016 Retour au numéro
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