Hospital-acquired Staphylococcus aureus primary bloodstream infection: A comparison of events that do and do not meet the central line–associated bloodstream infection definition - 31/10/16
, Cynthia Fatica, RN, BSN, CIC b, Robert Butler, MS c, Steven M. Gordon a, Thomas G. Fraser, MD a, bHighlights |
• | Staphylococcus aureus bloodstream infections in hospitalized patients are associated with significant mortality. |
• | Primary Staphylococcus aureus central line–associated bloodstream infections (CLABSIs) did not differ in their mortality compared with non-CLABSIs. |
• | Primary Staphylococcus aureus non–central line–associated bloodstream infections were associated with more bacteremic complications. |
• | Infected peripheral intravenous catheters and midlines are the etiology of most non–central line–associated bloodstream infection Staphylococcus aureus bacteremias. |
Abstract |
Background |
This study was done to describe the incidence and outcomes of primary hospital-acquired bloodstream infection (HABSI) secondary to Staphylococcus aureus (SA) that did and did not meet the National Healthcare Safety Network's (NHSN's) definition for central line–associated bloodstream infection (CLABSI).
Methods |
Consecutive hospitalized patients during a 48-month study period with an SA HABSI were categorized according to those who did and did not meet the NHSN's definitions for CLABSI and non-CLABSI. Primary outcomes were mortality at 30 days and 1 year. Secondary outcomes were the incidence of complicated bacteremia and the need for operative intervention secondary to the HABSI event.
Results |
A total of 122 episodes of primary SA HABSIs were identified: 78 (64%) were CLABSIs, and 44 (36%) were non-CLABSIs. Overall 30-day and 1-year mortality in the cohort was 21.3% and 38.5%, respectively, and did not differ significantly between the 2 groups. Complicated SA HABSI was significantly more common in the non-CLABSI group (15.9% [n = 7] vs 0% [n = 0], P ≤ .001).
Conclusions |
Primary SA HABSI was associated with significant 30-day and 1-year mortality. Complications from SA non-CLABSI requiring surgical intervention were significantly more common than in those with a CLABSI event. Our findings affirm the significance of non–device-related hospital-acquired infections.
Le texte complet de cet article est disponible en PDF.Key Words : Staphylococcus aureus, health care–associated bloodstream infection, primary bacteremia, infection surveillance, central line–associated bloodstream infection
Plan
| Conflicts of Interest: None to report. |
Vol 44 - N° 11
P. 1252-1255 - novembre 2016 Retour au numéro
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