Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin - 03/01/17

Doi : 10.1016/j.retram.2016.09.002

X. Kodji ^{^{1
Tel.: +44 2078 484 325.}}, A.A. Aubdool ^{^{1
Tel.: +44 2078 484 325.}}, S.D. Brain ^⁎,^{^{1
Tel.: +44 2078 484 325.}}
Cardiovascular Division, British Heart Foundation Centre of Excellence, King's College London, Faculty of Life Sciences and Medicine, 150, Stamford Street, SE1 9NH London, UK

^⁎Corresponding author. Tel.: +44 2078 484 453.

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Abstract

This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.

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Keywords : Sensory nerves, Transient receptor potential channels, Neuropeptides, Skin inflammation, Peripheral vasculature

Abbreviations : ATP, CFA, CGRP, CLR, CQ, DRG, GRPR, IL, IMQ, KO, Mrgpr, NADPH, NGF, NK1, nNOS, NO, PAR, PGE2, RAMP, RCP, ROS, SP, TNF-α, TRP, TRPA1, TRPV1, TSLP, WT, 4-ONE