Correlation between apparent diffusion coefficient value on diffusion-weighted MR imaging and Gleason score in prostate cancer - 03/01/17
, P. Reinikainen a, A. Vanhanen a, d, M. Kapanen a, d, T. Vierikko b, P. Ryymin b, S. Hyödynmaa d, P.-L. Kellokumpu-Lehtinen a, c
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Abstract |
Objectives |
To investigate whether diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) correlates with prostate cancer aggressiveness and further to compare the diagnostic performance of ADC and normalized ADC (nADC: normalized to non-tumor tissue).
Patients and methods |
Thirty pre-treatment patients (mean age, 69years; range: 59–78years) with prostate cancer underwent magnetic resonance imaging (MRI) examination, including DWI with three b values: 50, 400, and 800s/mm2. Both ADC and nADC were correlated with the Gleason score obtained through transrectal ultrasound-guided biopsy.
Results |
The tumor minimum ADC (ADCmin: the lowest ADC value within tumor) had an inverse correlation with the Gleason score (r=–0.43, P<0.05), and it was lower in patients with Gleason score 3+4 than in those with Gleason score 3+3 (0.54±0.11×103mm2/s vs. 0.64±0.12×10−3mm2/s, P<0.05). Both the nADCmin and nADCmean correlated with the Gleason score (r=–0.52 and r=–0.55, P<0.01; respectively), and they were lower in patients with Gleason score 3+4 than those with Gleason score 3+3 (P<0.01; respectively). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve was 0.765, 0.818, or 0.833 for the ADCmin, nADCmin, or nADCmean; respectively, in differentiating between Gleason score 3+4 and 3+3 tumors.
Conclusion |
Tumor ADCmin, nADCmin, and nADCmean are useful markers to predict the aggressiveness of prostate cancer.
Le texte complet de cet article est disponible en PDF.Keywords : Prostate cancer, MRI, Diffusion-weighted imaging, Apparent diffusion coefficient, Gleason score
Plan
Vol 98 - N° 1
P. 63-71 - janvier 2017 Retour au numéro
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