Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway - 03/01/17
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Betulinic acid (BA), a naturally occurring pentacyclic lupane group triterpenoid, has been demonstrated to protect against ischemia/reperfusion-induced renal damage. However, the effects of BA on cerebral ischemia/reperfusion (I/R) injury remain unclear. Hence, this study was to investigate the effects of BA on oxygen and glucose deprivation/reperfusion (OGD/R) induced neuronal injury in rat hippocampal neurons. Our results showed that BA pretreatment greatly attenuated OGD/R-induced neuronal injury. BA also inhibited OGD/R-induced intracellular ROS production and MDA level in rat hippocampal neurons. Furthermore, the down-regulation of Bcl-2, up-regulation of Bax and the consequent activation of caspase-3 induced by OGD/R were reversed by BA pretreatment. Mechanistic studies demonstrated that BA pretreatment up-regulated the expression levels of p-PI3K and p-Akt in hippocampal neurons induced by OGD/R. Taken together, these data suggested that BA inhibits OGD/R-induced neuronal injury in rat hippocampal neurons through the activation of PI3K/Akt signaling pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Betulinic acid (BA), Cerebral ischemia/reperfusion (I/R), Oxidative stress, Apoptosis
Plan
Vol 84
P. 1533-1537 - décembre 2016 Retour au numéro
Article précédent
- Alteration in Oxidative/nitrosative imbalance, histochemical expression of osteopontin and antiurolithiatic efficacy of Xanthium strumarium (L.) in ethylene glycol induced urolithiasis
- Padma Nibash Panigrahi, Sahadeb Dey, Monalisa Sahoo, Shyam Sundar Choudhary, Sumit Mahajan
- Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells
- Fengxia Yan, Rifang Liao, Mohd Farhan, Tinghuai Wang, Jiashu Chen, Zhong Wang, Peter J. Little, Wenhua Zheng
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?