MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury - 03/01/17
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 10 |
| Iconographies | 1 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene regulators. They are involved in the pathogenesis of different disorders including heart diseases. MiRNAs contribute to ischemia/reperfusion injury (I/RI) by altering numerous key signaling elements. Together with alterations in the various potential signaling pathways, modification in miRNA expression has been suggested as a part of the response network following ischemia/reperfusion (I/R). In addition, cardiac mitochondrial homeostasis is closely associated with cardiac function and impairment of mitochondrial activity occurred after ischemia/reperfusion injury. MiRNAs play a key role in the regulation of mitochondrial apoptotic pathway and signaling proteins. In this review, we summarize the knowledge currently available regarding the molecular mechanisms of miRNA-regulated mitochondrial functions during ischemia/reperfusion injury. This regulation occurs in different stages of mitochondrial apoptosis pathway.
Le texte complet de cet article est disponible en PDF.Abbreviations : MiRNA, I/R, O2−, ROS, MI, I/RI, PKCε, H/R, LNA, PDCD4, FasL, HSF1, AMI, Ad-miR-21, HIF-1, CDC42, eNOS, NO, MnSOD, Trx2, TR2, Prx3, Prx5, UCP-2, Ncx1, Mfn1, MFF, mPTP
Keyword : Ischemia/reperfusion, MicroRNA, Apoptosis, Mitochondria, Heart
Plan
Vol 84
P. 1635-1644 - décembre 2016 Retour au numéro
Article précédent
- Novel immunotherapeutic approaches for treatment of infertility
- Samaneh Abdolmohammadi-Vahid, Shahla Danaii, Kobra Hamdi, Farhad Jadidi-Niaragh, Majid Ahmadi, Mehdi Yousefi
- Development of T follicular helper cells and their role in disease and immune system
- Sadegh Eivazi, Salman Bagheri, Mohammad Sadegh Hashemzadeh, Majdedin Ghalavand, Elmira Safaie Qamsari, Ruhollah Dorostkar, Maryam Yasemi
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?