Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats - 03/01/17
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Highlights |
• | Chronic alcohol consumption causes several biochemical and biophysiological changes and leading to kidney dysfunction. |
• | Increased ROS and RNS are responsible for the kidney dysfunction. |
• | HPLC and in vitro analysis shows PSE contains large amount of bioactive compounds with strong radical scavenging activity. |
• | These bioactive compounds offers protection against alcohol-induced oxidative/nitrosative stress mediated kidney damage. |
Abstract |
The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed. PSE treatment to alcohol-administered rats effectively prevented the elevation in TBARS and NOx levels. Decreased activity of Na+/K+-ATPase in alcohol administered rats was brought to near normal levels with treatment of PSE. Chronic alcohol consumption affects antioxidant enzymatic activity and reabsorption function of the kidney which is evident from the decreased level of GSH as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione s-transferase (GST). However, treatment with PSE to alcohol-administered rats significantly enhanced these enzymatic activities and reduced glutathione (GSH) content close to normal level. Alcohol-induced organ damage was evident from morphological changes in the kidney. Nevertheless, administration of PSE effectively restored these morphological changes to normal. The flavonoid and tannoid compounds might have protective activity against alcohol-induced oxidative/nitrosative stress mediated kidney damage.
Le texte complet de cet article est disponible en PDF.Keywords : Alcohol, P. santalinus, Nephro-toxicity, Oxidative stress/Nitrosative stress
Plan
Vol 84
P. 740-746 - décembre 2016 Retour au numéro
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