A Thermographic Comparison of Irreversible Electroporation and Radiofrequency Ablation - 08/02/17
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Graphical abstract |
Highlights |
• | The new an experimental high-voltage generator for irreversible electroporation was constructed by authors and successfully tested ex vivo. |
• | The balloon electrode catheter – new prototype designed by authors – for irreversible electroporation was successfully tested ex vivo. |
• | There was documented the high increasing of temperature in case of radiofrequency ablation compare with irreversible electroporation. |
• | The proper function of irreversible electroporation device with new balloon catheter was documented with minimal thermal effect in tissue. |
• | Performed experiments showed the infrared camera as o tool suitable for monitoring of temperature change of tissue in realised experiments. |
Abstract |
Radiofrequency ablation and irreversible electroporation are both interventional procedures used in treating cancer diseases generally and may be used in treatment of liver cancer. The two differ in terms of their action and thermal effects. The present study examined thermal effects of radiofrequency ablation and modified irreversible electroporation ex vivo in porcine liver. Standard radiofrequency ablation was used during the experiments, as was a unique, experimental high-voltage generator of the research team's own construction coupled with a newly designed balloon electrode catheter for irreversible electroporation. The tested balloon catheter was newly designed for application in the biliary tract. The temperature of porcine liver tissue was monitored without contact by infrared camera. The results show significantly different temperature of tissue around electrodes for radiofrequency ablation and irreversible electroporation. The data obtained from radiofrequency ablation with maximum tested output power of 10 watts show a symmetrical area of tissue near active electrodes with temperature increased by more than 30 °C. Irreversible electroporation methods showed temperature increasing approximately by 5 °C. To summarize, the thermal research showed that the difference between standard RFA and innovated IRE with the balloon catheter lies not just in the differing mechanism of action, as is well known, but also in its thermal effects. There was documented that tissue temperature was much higher for RFA than for IRE, particularly for the maximum tested output parameters. The applicability of the newly designed balloon catheters was confirmed.
Le texte complet de cet article est disponible en PDF.Keywords : Temperature, Balloon catheter, Heating effect, Infrared camera, Irreversible electroporation, Radiofrequency ablation
Plan
Vol 38 - N° 1
P. 26-33 - février 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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