Neonatal Amygdala Functional Connectivity at Rest in Healthy and Preterm Infants and Early Internalizing Symptoms - 18/04/17
, Chad M. Sylvester, MD, PhD a, Carrie Mintz, MD a, Jeanette K. Kenley, BS a, Joshua S. Shimony, MD, PhD b, Deanna M. Barch, PhD a, b, c, Christopher D. Smyser, MD a, bAbstract |
Objective |
Alterations in the normal developmental trajectory of amygdala resting state functional connectivity (rs-FC) have been associated with atypical emotional processes and psychopathology. Little is known, however, regarding amygdala rs-FC at birth or its relevance to outcomes. This study examined amygdala rs-FC in healthy, full-term (FT) infants and in very preterm (VPT) infants, and tested whether variability of neonatal amygdala rs-FC predicted internalizing symptoms at age 2 years.
Method |
Resting state fMRI data were obtained shortly after birth from 65 FT infants (gestational age [GA] ≥36 weeks) and 57 VPT infants (GA <30 weeks) at term equivalent. Voxelwise correlation analyses were performed using individual-specific bilateral amygdala regions of interest. Total internalizing symptoms and the behavioral inhibition, depression/withdrawal, general anxiety, and separation distress subdomains were assessed in a subset (n = 44) at age 2 years using the Infant Toddler Social Emotional Assessment.
Results |
In FT and VPT infants, the amygdala demonstrated positive correlations with subcortical and limbic structures and negative correlations with cortical regions, although magnitudes were decreased in VPT infants. Neonatal amygdala rs-FC predicted internalizing symptoms at age 2 years with regional specificity consistent with known pathophysiology in older populations: connectivity with the anterior insula related to depressive symptoms, with the dorsal anterior cingulate related to generalized anxiety, and with the medial prefrontal cortex related to behavioral inhibition.
Conclusion |
Amygdala rs-FC is well established in neonates. Variability in regional neonatal amygdala rs-FC predicted internalizing symptoms at 2 years, suggesting that risk for internalizing symptoms may be established in neonatal amygdala functional connectivity patterns.
Le texte complet de cet article est disponible en PDF.Key words : infant, internalizing, amygdala, functional connectivity
Plan
| This work was supported by the National Institutes of Health (R01 HD057098, R01 HD061619, UL1 TR000448, KL2 TR000250, K23 MH105179, and K02 NS089852), McDonnell Center for Systems Neuroscience, Intellectual and Developmental Disabilities Research Center at Washington University (P30 HD062171), Child Neurology Foundation, Cerebral Palsy International Research Foundation, Dana Foundation, and Doris Duke Foundation. |
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| The authors thank the following individuals who assisted with this project: Karen Lukas, RN, Anthony Barton, Jessica Conners, Rachel Paul, BA, Jim Alexopoulous, MA, Joe Ackermann, Jr., BA, and Tara Smyser, MSE, all from Washington University School of Medicine. The authors also thank the families who participated. |
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| Disclosure: Dr. Barch has served as a consultant for Amgen, Pfizer, Takeda, and Roche and has a contract to analyze imaging data for Pfizer. Drs. Rogers, Sylvester, Mintz, Shimony, Smyser, and Ms. Kenley report no biomedical financial interests or potential conflicts of interest. |
Vol 56 - N° 2
P. 157-166 - février 2017 Retour au numéro
Article précédent
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