Peripheral Precocious Puberty due to Functioning Adrenocortical Tumor: Description of Two Cases - 18/04/17
, Giovanni Cobellis, MD, PhD 2, Diana Giobbi, MD 3, Cecilia Proietti Pannunzi, MD 1, Antonio Iannilli, MD 3, Valentino Cherubini, MD 3Abstract |
Background |
Adrenocortical tumors (ACTs) represent less than 0.2% of all childhood neoplasms. Frequent clinical manifestations are virilization, hypercortisolism, and peripheral precocious puberty (PPP).
Cases |
We describe two cases in which ACTs were responsible for virilization (case 1) and PPP (case 2) in prepubertal girls. In both cases an ACT diagnosis was made after 5-6 months from the first appearance of clinical signs. Surgery was performed within 1 month of diagnosis, and the benign nature of tumors was histologically confirmed. Despite complete tumor resection, virilizing features persisted.
Summary and Conclusions |
Adrenocortical tumors should be considered early in the assessment of PPP. There is often a significant delay between the onset of symptoms and accurate diagnosis but early treatment is essential to limit the clinical manifestations of androgen overproduction.
Le texte complet de cet article est disponible en PDF.Key Words : Peripheral precocious puberty, Virilization, Adrenocortical tumors
Plan
| The authors indicate no conflicts of interest. |
Vol 30 - N° 1
P. e1-e4 - février 2017 Retour au numéro
Article précédent
- Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study
- Hao Wu, Stephanie A. Pangas, Karen W. Eldin, Kalyani R. Patel, John Hicks, Jennifer E. Dietrich, Rajkumar Venkatramani
- Breast Cancer in a 19-Year-Old Female Adolescent Identified with Li-Fraumeni Syndrome
- Allison M. Jay, Anthony S. Hamame, Carrie Dul, Cheryl Wesen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?