White Matter Volume Predicts Language Development in Congenital Heart Disease - 18/04/17
Abstract |
Objective |
To determine whether brain volume is reduced at 1 year of age and whether these volumes are associated with neurodevelopment in biventricular congenital heart disease (CHD) repaired in infancy.
Study design |
Infants with biventricular CHD (n = 48) underwent brain magnetic resonance imaging (MRI) and neurodevelopmental testing with the Bayley Scales of Infant Development-II and the MacArthur-Bates Communicative Development Inventories at 1 year of age. A multitemplate based probabilistic segmentation algorithm was applied to volumetric MRI data. We compared volumes with those of 13 healthy control infants of comparable ages. In the group with CHD, we measured Spearman correlations between neurodevelopmental outcomes and the residuals from linear regression of the volumes on corrected chronological age at MRI and sex.
Results |
Compared with controls, infants with CHD had reductions of 54 mL in total brain (P = .009), 40 mL in cerebral white matter (P < .001), and 1.2 mL in brainstem (P = .003) volumes. Within the group with CHD, brain volumes were not correlated with Bayley Scales of Infant Development-II scores but did correlate positively with MacArthur-Bates Communicative Development Inventory language development.
Conclusions |
Infants with biventricular CHD show total brain volume reductions at 1 year of age, driven by differences in cerebral white matter. White matter volume correlates with language development, but not broader developmental indices. These findings suggest that abnormalities in white matter development detected months after corrective heart surgery may contribute to language impairment.
Trial registration |
ClinicalTrials.gov: NCT00006183.
Le texte complet de cet article est disponible en PDF.Keywords : brain, MRI, neurodevelopment, language, infant
Abbreviations : BSID-II, CDI, CHD, MDI, MRI, PDI, TGA, TOF
Plan
| Funded by the Pediatric Heart Network (PHN), supported by the National Heart, Lung, and Blood Institute/National Institutes of Health (NIH; U10HL068270), the NIH/National Institute of Neurological Disorders and Stroke (K12 NS079414, HL063411, RR02172), the Farb Family Fund, and the Boston Children's Hospital Intellectual And Developmental Disabilities Research Center (P30 HD18655). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest. |
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| Portions of the study were presented as a poster at the meeting of the Pediatric Academic Societies, April 30-May 3, 2016, Baltimore, MD. |
Vol 181
P. 42 - février 2017 Retour au numéro
Article précédent
- Congenital Heart Disease in Premature Infants 25-32 Weeks' Gestational Age
- Patricia Y. Chu, Jennifer S. Li, Andrzej S. Kosinski, Christoph P. Hornik, Kevin D. Hill
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- Melissa C. Bartick, Briana J. Jegier, Brittany D. Green, Eleanor Bimla Schwarz, Arnold G. Reinhold, Alison M. Stuebe
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