Prostate-specific Membrane Antigen-targeted Ligand Positron Emission Tomography/Computed Tomography and Immunohistochemical Findings in a Patient With Synchronous Metastatic Penile and Prostate Cancer - 19/04/17
, Friederike Kuithan b, Klaus Zöphel c, Ulrike Heberling a, Michael Laniado d, Manfred P. Wirth aAbstract |
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma. The interpretation of imaging in synchronous tumors should take this fact into consideration.
Le texte complet de cet article est disponible en PDF.| Financial Disclosure: The authors declare that they have no relevant financial interests. |
Vol 101
P. e5-e6 - mars 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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