Frontostriatal dysconnectivity in adolescent onset schizophrenia and its associations with cognition: An MRI volumetric and diffusion tensor imaging study - 08/07/17
Résumé |
Background |
Adolescent-onset schizophrenia (AOS) is associated with cognitive impairment and poor clinical outcome. Cognitive dysfunction is thought to reflect functional dysconnectivity between the frontal cortex and the striatum, Previous work [1] has shown frontostriatal dysconnectivity in large WM tracts explain core cognitive deficits, with processing speed, which is affected by alterations in WM connectivity, being an intermediary variable.
Objective |
To undertake a follow-up MRI study using whole-brain structural connectomics to track topological changes in the follow-up (1st episode versus follow-up), in order to characterize the early stages (evolution of the first two years) of the disorder.
Design |
A follow-up study of 25 AOS subjects and 25 age and sex-matched healthy subjects.
Outcome |
Network theory will be applied to identify topological alterations in structural networks, including frontostriatal white matter (WM) tracts in relation to cognition and outcome measures.
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Vol 41 - N° S
P. S59 - avril 2017 Retour au numéro
Article précédent
- Structural brain abnormalities in early onset psychosis: results from the norment eop cohort
- V. Lonning, S. Nerland, R.E. Smelror, T.P. Gurholt, I. Agartz
- Auditory cortex characteristics in early onset psychosis and its associations with auditory hallucinations: A structural MRI Study
- R.E. Smelror, V. Lonning, L. Mørch-Johnsen, S. Nerland, T. Gurholt, I. Agartz
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