Overactive Bladder Is Strongly Associated With Frailty in Older Individuals - 26/07/17

Doi : 10.1016/j.urology.2017.03.058

Anne M. Suskind ^a,^* , Kathryn Quanstrom ^a, Shoujun Zhao ^a, Mark Bridge ^a, Louise C. Walter ^b,^c, John Neuhaus ^d, Emily Finlayson ^e
^a Department of Urology, University of California, San Francisco, CA
^b Division of Geriatrics, University of California, San Francisco, CA
^c Division of Geriatrics, Veterans Affairs Medical Center, San Francisco, CA
^d Department of Epidemiology and Biostatistics, University of California, San Francisco, CA
^e Department of Surgery, University of California, San Francisco, CA

^*Address correspondence to: Anne M. Suskind, M.D., M.S., University of California, Department of Urology, 400 Parnassus Ave, Box 0738, San Francisco, CA 94143.University of CaliforniaDepartment of Urology400 Parnassus Ave, Box 0738San FranciscoCA94143

Abstract

Objective

To understand the relationship between age, frailty, and overactive bladder (OAB).

Materials and Methods

This is a prospective study of individuals age ≥65 years presenting to an academic urology practice between December 2015 and July 2016. All patients had a Timed Up and Go Test (TUGT), a parsimonious measure of frailty, on intake, and were thereby categorized as fast (≤10 seconds), intermediate (11-14 seconds), and slow (≥15 seconds). The TUGT and other clinical data were abstracted from the electronic medical record using direct queries. Logistic regression was used to examine the relationship between frailty and the diagnosis of OAB, adjusting for age, gender, and race.

Results

Our cohort included 201 individuals with and 1162 individuals without OAB. Individuals with OAB had slower TUGTs (13.7 ± 7.9 seconds) than their non-OAB counterparts (10.9 ± 5.2 seconds), P <.0001, with 32.3% and 11.0% of OAB and non-OAB individuals being categorized as slow, or frail. In multivariable analysis, slower TUGT was a significant predictor of OAB (adjusted odds ratio: 3.0; 95% confidence interval: 2.0-4.8). Age was not independently associated with this diagnosis (P values >.05 for each age group).

Conclusion

Patients with OAB are statistically significantly frailer than individuals seeking care for other non-oncologic urologic diagnoses. Frailty, when adjusted for age, race, and gender, is a statistically significant predictor of OAB. Furthermore, frailty should be considered when caring for older patients with OAB, and OAB should be assessed when caring for frail older patients.

Le texte complet de cet article est disponible en PDF.

Plan

Materials and Methods

Patients and Database

	Financial Disclosure: Anne M. Suskind was funded by K12 Urologic Research (KURe) Career Development Program. The remaining authors declare that they have no relevant financial interests.
	Funding Support: Dr. Suskind's time was funded by NIDDK K12 DK83021-07; K12 Urologic Research (KURe) Career Development Program.