Electrographic Seizures during the Early Postnatal Period in Preterm Infants - 26/07/17
Abstract |
Objective |
To investigate the frequency and characteristics of electrographic seizures in preterm infants in the early postnatal period.
Study design |
Infants <32 weeks gestational age (GA) (n = 120) were enrolled for continuous multichannel electroencephalography (EEG) recording initiated as soon as possible after birth and continued for approximately up to 72 hours of age. Electrographic seizures were identified visually, annotated, and analyzed. Quantitative descriptors of the temporal evolution of seizures, including total seizure burden, seizure duration, and maximum seizure burden, were calculated.
Results |
Median GA was 28.9 weeks (IQR, 26.6-30.3 weeks) and median birth weight was 1125 g (IQR, 848-1440 g). Six infants (5%; 95% CI, 1.9-10.6%) had electrographic seizures. Median total seizure burden, seizure duration, and maximum seizure burden were 40.3 minutes (IQR, 5.0-117.5 minutes), 49.6 seconds (IQR, 43.4-76.6 seconds), and 10.8 minutes/hour (IQR, 1.6-20.2 minutes/hour), respectively. Seizure burden was highest in 2 infants with significant abnormalities on neuroimaging.
Conclusion |
Electrographic seizures are infrequent within the first few days of birth in very preterm infants. Seizures in this population are difficult to detect accurately without continuous multichannel EEG monitoring.
Le texte complet de cet article est disponible en PDF.Keywords : neonate, premature, seizure activity, continuous multichannel EEG
Abbreviations : AED, aEEG, BW, cPVL, CRIB, CUS, EEG, GA, IVH, NICU
Plan
| Funded by a Science Foundation Research Centre Award (INFANT-12/RC/2272). J.O.T. received financial support from the Irish Research Council (GOIPD/2014/396). Some data collection was also supported by the Wellcome Trust UK (085249). The authors have no conflicts of interest. |
Vol 187
P. 18 - août 2017 Retour au numéro
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