Relationship Between Birth Weight and the Double Product in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study) - 29/08/17

Doi : 10.1016/j.amjcard.2017.06.037

Fu Wang, MD, MS ^a,^{^{1
These authors contributed equally to this work.}}, Yingxiao Hua, MD, MPH ^a,^{^{1
These authors contributed equally to this work.}}, Paul K. Whelton, MD ^a, Tao Zhang, MD, PhD ^a,^b, Camilo Alonso Fernandez, MD, MS ^a, Huijie Zhang, MD, PhD ^c, Lydia Bazzano, MD, PhD ^a, Jiang He, MD, PhD ^a, Wei Chen, MD, PhD ^a, Shengxu Li, MD, PhD ^a,^*
^a Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
^b Department of Biostatistics, School of Public Health, Shandong University, Jinan, China
^c Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, Xiamen, China

^*Corresponding author: Tel: (504) 988-1048; fax: (504) 988-1568.

Abstract

Low birth weight is associated with cardiovascular disease and its risk factors, including heart rate and blood pressure. Therefore, we examined the hypothesis that birth weight is related to blood pressure-heart rate product (double product, DP), an index of oxygen consumption and workload of the heart, at different ages. Heart rate at rest, blood pressure at rest, and birth weight data were available in 2,340 children (4 to 11 years), 1,621 adolescents (12 to 19 years), and 2,315 adults (20 to 52 years) from the Bogalusa Heart Study (total n = 6,276). After adjustment for age, sex, race, and body mass index, gestational age-adjusted birth weight was inversely associated with DP, with per 100-g decrease in birth weight associated with an increase of 12.8, 22.9, and 23.2 beats/min × mmHg in DP in children (p = 0.016), adolescents (p = 0.0007), and adults (p = 0.0006), respectively. An amplifying trend of the association with age was observed in the total sample (p = 0.002). In conclusion, birth weight is associated with increased DP beginning in childhood, which may partly mediate the association between low birth weight and increased cardiovascular risk later in life.

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This study was supported by grants 5R01ES021724 from National Institute of Environmental Health Science and AG-041200 from the National Institute on Aging. Fu Wang was supported by award 201406370184 from the State Scholarship Fund of the China Scholarship Council. Shengxu Li is partly supported by grant 13SDG14650068 from American Heart Association and grant 1P20GM109036-01A1 from National Institute of General Medical Sciences.

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Vol 120 - N° 6

P. 1016-1019 - septembre 2017 Retour au numéro

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Relationship Between Birth Weight and the Double Product in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study) - 29/08/17

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