Biomaterials for Craniofacial Bone Regeneration - 07/09/17

Doi : 10.1016/j.cden.2017.06.003

Greeshma Thrivikraman, PhD ^a, Avathamsa Athirasala, MS ^a, Chelsea Twohig, DDS ^a, Sunil Kumar Boda, PhD ^b, Luiz E. Bertassoni, DDS, PhD ^a,^c,^d,^⁎
^a Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, OHSU School of Dentistry, 2730 SW Moody Avenue, Portland, OR 97201, USA
^b Mary and Dick Holland Regenerative Medicine Program, Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, NE 68198-5965, USA
^c Department of Biomedical Engineering, OHSU School of Medicine, 3303 SW Bond Avenue, Portland, OR 97239, USA
^d OHSU Center for Regenerative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA

^∗Corresponding author. Department of Restorative Dentistry, OHSU School of Dentistry, 2730 SW Moody Avenue, Portland, OR 97201.Department of Restorative DentistryOHSU School of Dentistry2730 SW Moody AvenuePortlandOR97201

Résumé

Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.

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Keywords : Tissue engineering, Stem cells, 3D bioprinting, Gene delivery, Growth factor delivery, Bone regeneration, Calcium phosphate