Population-based Semen Analysis Results and Fertility Among Patients With Inflammatory Bowel Disease: Results From Subfertility Health Assisted Reproduction and the Environment (SHARE) Study - 09/09/17
, Sheala Mullaney b, William Peche a, Kathryn Peterson c, Stephanie Chan c, Ryan Morton c, Yuan Wan d, Chong Zhang e, Angela P. Presson e, Benjamin Emery b, Kenneth Aston b, Timothy Jenkins b, Douglas Carrell b, James Hotaling bAbstract |
Objective |
To evaluate male fertility in Crohn disease (CD) and ulcerative colitis (UC) by examining semen analysis results and paternity from the SHARE study (Subfertility Health Assisted Reproduction and the Environment), a population-based cohort of semen analysis results from Utah men.
Methods |
A population-based cohort of men with CD or UC was identified using the Utah Population Database (contains person-level linked demographic, genealogical, and medical record information for 85% of Utahans) from 1996 to 2014, and validated by clinical chart review. This cohort was then cross-linked (n = 55) to the SHARE population dataset of semen analysis results. Men with CD or UC were compared with population-based, age-matched, paired (1:1) controls (n = 47). Paternity was evaluated though presence and number of linked offspring and inter-birth interval.
Results |
Offspring were identified in 71% of UC patients (mean of 1.8 children) and 61% of CD patients (mean of 1.2 children). Compared with matched controls, there were no differences in number of offspring, mean inter-birth interval, or any of the evaluated semen analysis parameters among either men with CD or UC.
Conclusion |
Fertility and semen analysis values among men with UC or CD are not significantly impacted compared with population-based, age-matched controls.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
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| Funding Support: This study was funded by the co-author, Dr. William Peche, and by the Department of Surgery at the University of Utah. Indirect financial support in part for the Utah Study Design and Biostatistics Center and the Utah Population Database are as follows: |
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| Statistical Section Support |
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| “The statistical section was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 5UL1TR001067-02 (formerly 8UL1TR000105 and UL1RR025764).” |
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| Utah Population Database Support |
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| “We thank the Pedigree and Population Resource of the Huntsman Cancer Institute, University of Utah (funded in part by the Huntsman Cancer Foundation) for its role in the ongoing collection, maintenance and support of the Utah Population Database (UPDB). We also acknowledge partial support for the UPDB through grant P30 CA2014 from the National Cancer Institute, University of Utah and from the University of Utah's Program in Personalized Health and Center for Clinical and Translational Science.” |
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| “We thank the University of Utah Center for Clinical and Translational Science (CCTS) (funded by NIH Clinical and Translational Science Awards), the Pedigree and Population Resource, University of Utah Information Technology Services and Biomedical Informatics Core for establishing the Master Subject Index between the Utah Population Database, the University of Utah Health Sciences Center and Intermountain Health Care.” |
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| “Research was supported by the NCRR grant, ‘Sharing Statewide Health Data for Genetic Research’ (R01 RR021746, G. Mineau, PI) with additional support from the Utah State Department of Health and the University of Utah.” |
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| Meeting Presentation: These data were presented as Poster Presentation at the American Society of Andrology, 42nd Annual Conference in Miami, FL, on April 23d, 2017. |
Vol 107
P. 114-119 - septembre 2017 Retour au numéro
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