ACTH therapy in infantile spasms: Relationship between dose of ACTH and initial effect or long-term prognosis - 06/10/17
Abstract |
The relationship between the dose of ACTH and the initial effect was investigated in 41 children with infantile spasms. More than 0.015 mg (0.6 IU)/kg/day of ACTH was needed for a good initial response of seizures and electroencephalographic abnormalities. The relationship between the dose of ACTH and long-term prognosis was investigated in 29 patients. There was no relationship between the daily or total ACTH dosage, provided the dose was > 0.015 mg (0.6 IU)/kg/day, and the outcome of seizures and electroencephalographic abnormalities; however, ACTH 0.04–0.06 mg (1.6–2.4 IU)/kg/day and a total ACTH dose of 1.1–1.5 mg (44–60 IU)/kg resulted in better mental development than smaller doses of ACTH. Side effects of ACTH increased with dosage. Too small or too large a dose of ACTH does not lead to better mental development. The proper dose of ACTH should be used with careful attention to potential side effects.
Le texte complet de cet article est disponible en PDF.Vol 6 - N° 4
P. 240-244 - juillet 1990 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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