Insulin and glucose requirements during the first stage of labor in insulin-dependent diabetic women - 07/10/17
Abstract |
Studies utilizing glucose-controlled insulin infusion systems were undertaken to more accurately define the glucose and insulin requirements during the first stage of labor induced by oxytocin in 12 insulin-dependent diabetic women in whom normoglycemia had been maintained before delivery. Insulin requirements decreased to zero during active stage 1 labor, while the glucose infusion rate necessary to maintain a blood glucose level of 70 to 90 mg/dl (or 3.9 to 5.0 mmol/liter) was constant at 2.55 mg/kg per minute. The findings were confirmed in 40 additional studies of oxytocin-induced labor. Studies of six women undergoing spontaneous labor and one nonpregnant woman receiving oxytocin confirmed that the decrement in the insulin requirement during stage 1 labor was not influenced by oxytocin infusion. The changes occurred regardless of whether epidural anesthesia was employed. Insulin requirements returned during the second stage of labor. Active stage 1 labor in diabetic women thus appears to be associated with a predictable decrease in the need for insulin and a constant glucose requirement.
Le texte complet de cet article est disponible en PDF.☆ | This research was supported in part by the Leonard Sheriff Fund, a clinical grant from the National Foundation, March of Dimes (6-178), Grant RR-47 from the National Institutes of Health, General Clinical Research Centers Branch, and the New York Diabetes Association. |
Vol 75 - N° 4
P. 607-612 - octobre 1983 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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