Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease - 12/10/17
Abstract |
We studied phagocyte reduced nicotinamide adenine dinucleotide phosphate function to evaluate production of reactive oxygen species in both X-linked and autosomal forms of chronic granulomatous disease. We found a consistent and significant difference between the activated granulocyte response of the X-linked (gp91-phagocyte oxidase) form of chronic granulomatous disease (n = 18) and that of the most common autosomal recessive (p47-phagocyte oxidase) form of the disease (n = 17). The data indicate that mutations in the p47-phagocyte oxidase component of the reduced nicotinamide adenine dinucleotide phosphate oxidase component do not completely prevent oxidation despite severe defects in superoxide generation. (J PEDIATR 1996;128:104-7)
Le texte complet de cet article est disponible en PDF.Abbreviations : CGD, CV, DHR, NADPH, phox, SEM, SI
Plan
 | From the Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, and the Immunology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland |
| Reprint requests: Sarah J. Vowells, MD, Department of Health and Human Services, National Institutes of Health, Bldg. 10, Room 2C-140, Bethesda, MD 20892. |
 | 9/22/69136 |
Vol 128 - N° 1
P. 104-107 - janvier 1996 Retour au numéro
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