Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants - 01/11/17
, Sayuri Nakahara, MD, Yoshihiro Maruo, MD, PhDAbstract |
Objective |
To determine whether a variant of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1*6) is a risk factor for prolonged hyperbilirubinemia in preterm infants.
Study design |
UGT1A1 genotypes in 46 Japanese preterm infants (<37 weeks of gestation) were compared with UGT1A1 genotypes in 38 control infants, using polymerase chain reaction-direct sequencing. Prolonged unconjugated hyperbilirubinemia was defined as serum total bilirubin concentration of >150 µmol/L (8.77 mg/dL) beyond 14 days of life.
Results |
In the case group, 41 of 46 infants (89.1%) had a polymorphic variant, c.211G>A, p.G71R (UGT1A1*6). In the control group, 7 of 38 (18.4%) had UGT1A1*6. The allele frequency of UGT1A1*6 was 0.641 in the prolonged hyperbilirubinemia group, which was significantly higher than in the control group (0.092; P < .001). In total, 39 of 46 infants in the case group were breast fed, and only 10 infants in the control group were breast fed.
Conclusions |
These data suggest that UGT1A1*6 is a risk factor for prolonged unconjugated hyperbilirubinemia in preterm infants in Japan. Given the different rate of breast feeding in this study, additional data are necessary for drawing a definitive conclusion.
Le texte complet de cet article est disponible en PDF.Keywords : p.G71R, UGT1A1, premature baby, jaundice, neonatal hyperbilirubinemia
Abbreviation** : UGT1A1
Plan
| The authors declare no conflicts of interest. |
Vol 190
P. 159 - novembre 2017 Retour au numéro
Article précédent
- Trial of Music, Sucrose, and Combination Therapy for Pain Relief during Heel Prick Procedures in Neonates
- Swapnil R. Shah, Shahajahan Kadage, John Sinn
- Shifting Risks and Conflicting Outcomes—ECMO for Neonates with Congenital Diaphragmatic Hernia in the Modern Era
- Joseph W. Turek, Joseph R. Nellis, Brenton G. Sherwood, Meera Kotagal, Andrew L. Mesher, Ravi R. Thiagarajan, Sonali S. Patel, Jeffrey R. Avansino, Peter T. Rycus, D. Michael McMullan, Thomas V. Brogan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?