Intracoronary Optical Coherence Tomography-Derived Virtual Fractional Flow Reserve for the Assessment of Coronary Artery Disease - 07/11/17
, Teruyoshi Uetani, MD a, Kazuhisa Nishimura, MD a, Hiroshi Kawakami, MD a, Haruhiko Higashi, MD a, Jun Aono, MD a, Takayuki Nagai, MD a, Katsuji Inoue, MD a, Jun Suzuki, MD a, Hideo Kawakami, MD b, Takafumi Okura, MD a, Kazunori Yasuda, PhD c, Jitsuo Higaki, MD a, Shuntaro Ikeda, MD aAbstract |
Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Optical coherence tomography (OCT) provides accurate visualization of coronary artery morphology. The aim of this study was to investigate the relation between FFR and OCT-derived FFR. We retrospectively analyzed 31 lesions (25 left anterior descending arteries, 2 left circumflex arteries, and 4 right coronary arteries) in 31 patients with moderate-to-severe coronary stenosis, who underwent OCT and FFR measurements simultaneously. OCT-derived FFR was calculated by the original algorithm, which was calculated using the following equation based on fluid dynamics: ΔP = FV + SV2, where V is the flow velocity, F is the coefficient of pressure loss because of viscous friction (Poiseuille resistance), and S is the coefficient of local pressure loss because of abrupt enhancement (flow separation). Mean values of % diameter stenosis by quantitative coronary angiography and FFR were 55.2 ± 14.0% and 0.70 ± 0.14, respectively. OCT-derived FFR showed a stronger linear correlation with FFR measurements (r = 0.89, p <0.001; root mean square error = 0.062 FFR units) than quantitative coronary angiography % diameter stenosis (r = −0.65, p <0.001), OCT measurements of minimum lumen area (r = 0.68, p <0.001), and % area stenosis (r = −0.70, p <0.001). OCT-derived FFR has the potential to become an alternative method for the assessment of functional myocardial ischemia, and may elucidate the relation between coronary morphology and FFR.
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| This work was supported by JSPS KAKENHI Grant Numbers 10771561. |
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| See page 1778 for disclosure information. |
Vol 120 - N° 10
P. 1772-1779 - novembre 2017 Retour au numéro
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