Reference values for skin microanatomy: A systematic review and meta-analysis of ex vivo studies - 23/11/17
Abstract |
Background |
Few studies have characterized reference values of normal human skin microanatomy parameters.
Objective |
To quantify histologic measurements of epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density as a function of age and anatomic site.
Method |
We searched the PubMed, Embase, Web of Science, and Cochrane databases for articles published through May 25, 2017. Two reviewers independently screened 2016 articles; 327 relevant articles and 151 additional articles found via forward or reference citations underwent full-text review by 1 of 4 reviewers for relevance, data extraction, and critical appraisal. Weighted averages, meta-analysis, and meta-regression were used in statistical analysis.
Results |
A total of 56 articles were included; when all anatomic locations were used, the overall estimates for epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density were 99.75 μm (95% confidence interval [CI], 83.25-116.25), 955.05 cells/mm2 (95% CI. 880.89-1029.21), 1.40 hairs/mm2 (95% CI. 0.91-1.89), and 1.28 glands/mm2 (95% CI. 0.91-1.64), respectively.
Limitations |
There was significant data heterogeneity across studies, possibly because of differences in histological techniques and absence of standardized microanatomy definitions.
Conclusions |
We established summary estimates for normal human skin microanatomy parameters.
Le texte complet de cet article est disponible en PDF.Key words : eccrine gland density, epidermal thickness, hair follicle density, melanocyte density, normal-appearing skin, systematic review
Abbreviations used : CI, EGD, ET, GET, HFD, MD, SCT
Plan
Mr Xu, Dr Fonseca, and Mr Wolner contributed equally to this article. |
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Supported in part through National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 77 - N° 6
P. 1133 - décembre 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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