Risk factors for methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit: A systematic review and meta-analysis - 29/11/17
, Jon Woltmann, MD, Beth Haberman, MD, David Haslam, MD, Mary Allen Staat, MD, MPHHighlights |
• | Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of infection within neonatal intensive care units. |
• | Very preterm and very-low birth weight infants are at an increased risk for MRSA colonization. |
• | Infection prevention efforts should target these high-risk infants. |
Abstract |
Context |
Methicillin-resistant Staphylococcus aureus (MRSA) causes a significant burden of illness in neonatal intensive care units (NICUs) worldwide. Identifying infants colonized with MRSA has become an important infection control strategy to interrupt nosocomial transmission.
Objective |
Assess risk factors for MRSA colonization in NICUs via a systematic review and meta-analysis.
Data sources |
MEDLINE, Embase, Web of Science, and The Cochrane Library databases were searched from inception through September 2015.
Study selection |
Studies reporting risk factors for MRSA colonization using noncolonized controls in subspecialty level III or IV NICUs were included.
Data extraction |
Two authors independently extracted data on MRSA colonization risk factors, study design, and MRSA screening methodology.
Results |
Eleven articles were included in the systematic review, with 10 articles analyzed via meta-analysis. MRSA colonization was associated with gestational age <32 weeks (odds ratio [OR], 2.67; 95% confidence interval [CI], 1.35-5.27; P = .01) and birth weight <1,500 g (OR, 2.63; 95% CI, 1.25-5.55; P = .01). Infant sex (P = .21), race (P = .06), inborn status (P = .09), and delivery type (P = .24) were not significantly associated with colonization.
Conclusions |
Very preterm and very-low birth weight infants were identified as having an increased risk for MRSA colonization on meta-analysis. Multifaceted infection prevention strategies should target these high-risk infants to reduce MRSA colonization rates in NICUs.
Le texte complet de cet article est disponible en PDF.Key Words : MRSA, Colonization, Epidemiology, NICU, Risk factors
Plan
| Conflicts of interest: None to report. |
Vol 45 - N° 12
P. 1388-1393 - décembre 2017 Retour au numéro
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