Classification of Chronic Rhinosinusitis—Working Toward Personalized Diagnosis - 14/12/17
Résumé |
An estimated 4.5% of total US health care dollars have been devoted to mitigating chronic rhinosinusitis. The most recalcitrant of these patients undergo surgery, which fails to improve symptoms in approximately 25% of patients. Recent advances in informational, microbiomic, and genomic analysis have introduced the first set of tools that patients, physicians, politicians, and payers can apply to better forecast which patients will respond favorably to endoscopic sinus surgery. This article summarizes the forces driving the application of personalized medicine to CRS and how new advances can be applied to clinical practice.
Le texte complet de cet article est disponible en PDF.Keywords : Chronic rhinosinusitis, Precision medicine, Personalized medicine, Microbiome, Cluster analysis, Phenotype, Endotype, Epidemiology
Plan
| Potential Conflicts of Interest: None. |
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| Financial Disclosures: A.S. DeConde and T.L. Smith are consultants for IntersectENT, Incorporated (Menlo Park, California), which is not affiliated with this article. T.L. Smith is supported by a grant for this investigation from the National Institute on Deafness and Other Communication Disorders (NIDCD), one of the National Institutes of Health, Bethesda, Maryland (R01 DC005805; PI/PD: T.L. Smith). |
Vol 50 - N° 1
P. 1-12 - février 2017 Retour au numéro
Article précédent
- Refractory Chronic Rhinosinusitis
- Abtin Tabaee, Edward D. McCoul
- Genetic and Immune Dysregulation in Chronic Rhinosinusitis
- Ashleigh Halderman, Andrew P. Lane
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