Hydrogen concentration is a critical determinant of many physiologic functions and is tightly regulated. Any alteration in acid-base equilibrium sets into motion a compensatory response by either the lungs or the kidneys. The compensatory response attempts to return the ratio between Pco₂ and [HCO₃⁻] to normal and thereby minimize the pH change. A primary increase or decrease in one component is associated with a predictable compensatory change in the same direction in the other component, and the expected compensation can be estimated clinically in dogs and cats.