The role of gallium-68 (⁶⁸Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that ⁶⁸Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of ⁶⁸Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic ⁶⁸Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.