Cardiovascular disease in children comprises a diverse collection of diseases involving multiple organ systems. Abnormality in children is predominately congenital but also may be acquired. Although noninvasive vascular imaging modalities such as magnetic resonance angiography and ultrasound lack ionizing radiation, with improving technology and an increased focus on radiation dose reduction, computed tomographic angiography (CTA) continues to have a role in evaluating cardiovascular disease in pediatric patients. This review focuses on specific considerations of CTA that the radiologist or ordering provider should consider when imaging the pediatric cardiovascular system.