Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder - 02/02/18
Abstract |
Objective |
Longitudinal neuroimaging during adolescence/young adulthood, when bipolar disorder (BD) commonly emerges, can help elucidate the neurodevelopmental pathophysiology of BD. Adults with BD have shown reduced structural integrity in the uncinate fasciculus (UF), a white matter (WM) tract providing major connections between the amygdala and ventral prefrontal cortex (vPFC), important in emotion regulation. In this longitudinal diffusion tensor imaging (DTI) study of adolescents/young adults, we hypothesized differences in age- and time-related changes in UF integrity in BD compared to healthy controls (HC).
Method |
Two DTI scans were obtained in 27 adolescents/young adults with BD and 37 HC adolescents/young adults, on average approximately 2.5 years apart. Interactions between diagnosis with age and with time for UF fractional anisotropy (FA) were assessed. Exploratory analyses were performed including euthymic-only participants with BD, and for potential influences of demographic and clinical factors. Whole-brain analyses were performed to explore for interactions in other regions.
Results |
There were significant interactions between diagnosis with age and with time for UF FA (p < .05). Healthy control adolescents/young adults showed significant UF FA increases with age and over time (p < .05), whereas no significant changes with age or over time were observed in the adolescents/young adults with BD. Significant interactions with age and time were also observed in analyses including euthymic-only participants with BD (p < .05).
Conclusion |
These findings provide neuroimaging evidence supporting differences in UF WM structural development during adolescence/young adulthood, suggesting that differences in the development of an amygdala−vPFC system subserving emotion regulation may be a trait feature of BD neurodevelopment.
Le texte complet de cet article est disponible en PDF.Key words : bipolar disorder, diffusion tensor imaging, adolescent, white matter
Plan
| The authors were supported by research grants from the National Institute of Health (NIH) RC1MH088366 (H.P.B.), R01MH070902 (H.P.B.), R01MH069747 (H.P.B.), T32MH014276 (E.T.C.L.), T32DA022975 (E.T.C.L.), and K01MH086621 (F.W.); American Foundation for Suicide Prevention (H.P.B., E.T.C.L.); International Bipolar Foundation (H.P.B.); Brain and Behavior Research Foundation (H.P.B., F.W.); Women's Health Research at Yale (H.P.B.); and the John and Hope Furth Professorship (H.P.B.). The funding sources had no involvement in the study design, collection, analysis, or interpretation of the data, writing the report, or decision to submit the article for publication. |
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| Mr. Pittman served as the statistical expert for this research. |
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| The authors thank Ralitza Gueorguieva, PhD, Todd Constable, PhD, and Cheryl Lacadie, BS, of Yale University, for their expert input and the research subjects for their participation. The authors also thank all the members of the Mood Disorders Research Program Team. |
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| Disclosure: Drs. Weathers, Lippard, Wang, Blumberg, Ms. Spencer, and Mr. Pittman report no biomedical financial interests or potential conflicts of interest. |
Vol 57 - N° 2
P. 111-117 - février 2018 Retour au numéro
Article précédent
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