Hypercoagulability and Vascular Disease - 21/02/18
Doi : 10.1016/j.hoc.2017.11.001
Ali T. Taher, MD, PhD, FRCP a, ⁎ 
, Maria Domenica Cappellini, MD b, c, Rayan Bou-Fakhredin, BSc d, Daniel Coriu, MD, PhD e, Khaled M. Musallam, MD, PhD f
, Maria Domenica Cappellini, MD b, c, Rayan Bou-Fakhredin, BSc d, Daniel Coriu, MD, PhD e, Khaled M. Musallam, MD, PhD f a Department of Internal Medicine, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, PO Box 11-0236, Beirut 11072020, Lebanon
b Department of Medicine, Ca' Granda Foundation IRCCS, Milan 20122, Italy
c Department of Clinical Science and Community, University of Milan, Milan 20122, Italy
d Department of Internal Medicine, American University of Beirut Medical Center, Beirut 11072020, Lebanon
e Department of Hematology, Fundeni Clinical Institute, University of Medicine and Pharmacy “Carol Davila”, Bucharest 030167, Romania
f International Network of Hematology, London WC1V 6AX, UK
∗Corresponding author.
Résumé |
The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia. It also discusses the clinical experience and available evidence on prevention and management approaches.
Le texte complet de cet article est disponible en PDF.Keywords : Thrombosis, Pulmonary hypertension, Cerebrovascular disease, Hypercoagulable state
Plan
| Conflicts of Interest: None to disclose. |
© 2017
Elsevier Inc. Tous droits réservés.
Vol 32 - N° 2
P. 237-245 - avril 2018 Retour au numéro
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