Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children - 28/02/18
Doi : 10.1016/j.jaci.2017.08.023
Peggy S. Lai, MD, MPH a, b, c, Amir H. Massoud, MD c, d, Mingcan Xia, MD, PhD c, d, Carter R. Petty, MA e, Amparito Cunningham, MD, MPH c, Talal A. Chatila, MD, MSc c, d, Wanda Phipatanakul, MD, MS c, d 
a Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, Mass
b Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass
c Harvard Medical School, Boston, Mass
d Allergy and Immunology, Boston Children's Hospital, Boston, Mass
e Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Mass
| This work was supported in part by the National Institutes of Health (grant nos. R01 AI 073964, U01 AI 110397, K24 AI 106822, and U01 AI 126614 to W.P, grant no. R01 AI065617 to T.A.C., grant no. K23 ES023700 to P.S.L, grant no. P30 ES000002 to Doug Dockery [PI], and grant no. 5T32AI007512 to M.X.). This work was also supported by the American College of Allergy, Asthma, and Immunology Young Faculty Award. This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH Award no. UL1 TR001102) and financial contributions from Harvard University and its affiliated academic health care centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the National Institutes of Health. |
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| Disclosure of potential conflict of interest: M. Xia's and T. A. Chatila's institute received support (grant no. R01AI065617) from the National Institutes of Health for this work. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2017
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 141 - N° 2
P. 794 - février 2018 Retour au numéro
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