Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants - 28/02/18
Doi : 10.1016/j.jaci.2017.10.001
X.F. Colin C. Wong, BSc a, ∗, Simon L.I.J. Denil, PhD a, ∗, Jia Nee Foo, PhD b, c, Huijia Chen, PhD a, Angeline Su Ling Tay, PhD a, Rebecca L. Haines, PhD a, Mark B.Y. Tang, MD d, W.H. Irwin McLean, DSc, FRS e, Aileen Sandilands, PhD e, Frances J.D. Smith, PhD e, E. Birgitte Lane, PhD a, Jianjun Liu, PhD b, John E.A. Common, PhD a 
a Institute of Medical Biology, A*STAR, Singapore, Singapore
b Genome Institute of Singapore, A*STAR, Singapore, Singapore
c Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
d National Skin Centre, Singapore, Singapore
e Dermatology and Genetic Medicine, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
| This work was funded by A*STAR Strategic Positioning Fund (SPF) grants for basic and translational skin research (grant nos. IAF SPF 2013/004 and IAF SPF 2013/005 to J.E.A.C., E.B.L., J.N.F., S.L.I.J.D., and J.L.), and A*STAR SPF grant for genetic orphan diseases (grant no. IAF SPF 2012/005 to X.F.C.C.W.). A.S and F.J.D.S. were supported by a Wellcome Trust Strategic Award (grant no. 098439) to W.H.I.M. |
|
| All sequencing files were submitted to NCBI Sequence Read Archive (SRA) and are publicly available under BioProject ID “PRJNA360024.” Accession codes for the individual samples are included in Table E9 in this article's Online Repository at www.jacionline.org. |
|
| Disclosure of potential conflict of interest: S. L. I. J. Denil received a grant from A*STAR, Institute of Medical Biology. J. E. A. Common received grants from GSK and A*STAR, Institute of Medical Biology; and payments for lectures from Galderma. C. Wong received a grant from A*STAR, Institute of Medical Biology. E. B. Lane received grants from GSK and A*STAR, Institute of Medical Biology. A. S. L. Tay received a grant from A*STAR, Institute of Medical Biology. A. Sandilands was funded by a grant from the Wellcome Trust (to W.H.I. McLean). W. H. I. McLean and F. J. D. Smith (University of Dundee) have registered patents for genetic testing and sequencing of FLG. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2017
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 141 - N° 2
P. 814-816 - février 2018 Retour au numéro
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