Association of subungual melanoma and subungual squamous cell carcinoma: A case series - 14/03/18
Abstract |
Background |
Subungual squamous cell carcinoma (SSCC) and subungual melanoma (SUM) are rare tumors. Several case reports of association of SSCC with SUM (SSCC-SUM) have been published.
Objective |
We sought to document the clinical, dermoscopic, and histologic features in a case series of SSCC-SUMs and describe their relative frequency compared with those of SSCC and SUM.
Methods |
All patients who underwent surgical exploration of the nail apparatus with a dermatopathologic examination from 2012 to 2015 were reviewed retrospectively to identify all cases of SSCC, SUM, and SSCC-SUM. For patients with SSCC-SUM, clinical characteristics were obtained from electronic medical records. All histologic specimens were reviewed by 3 dermatopathologists.
Results |
The medical records of 456 patients were reviewed. SSCC was diagnosed in 78 (17%), SUM was diagnosed in 63 (14%), and SSCC-SUM was diagnosed in 9. Patients with SSCC-SUM accounted for 11% of those with a diagnosis of SSCC (9 of 78) and 14% of those with a diagnosis of SUM (9 of 63).
Limitations |
This was a single-institution retrospective study.
Conclusion |
The association of SSCC and SUM is relatively frequent in patients with SUM and warrants further consideration to understand the underlying mechanisms involved.
Le texte complet de cet article est disponible en PDF.Keys words : association, confocal microscopy, dermatopathology, dermoscopy, squamomelanocytic tumor, subungual epidermoid carcinoma, subungual melanoma, subungual squamous cell carcinoma, SSCC, SUM
Abbreviations used : HPV, MM, SCC, SD, SSCC, SUM, SSCC-SUM
Plan
| Dr Boespflug is currently receiving a grant for her PhD studies from the Fondation pour la Recherche Médicale (grant FDM20150633361). No other support has been declared for this study. The funding source had no role in the study's conception, data acquisition, manuscript preparation, or manuscript review. |
|
| Conflicts of interest: None disclosed. |
|
| Reprints not available from the authors. |
Vol 78 - N° 4
P. 760-768 - avril 2018 Retour au numéro
Article précédent
- Serration pattern analysis for differentiating epidermolysis bullosa acquisita from other pemphigoid diseases
- Joost M. Meijer, Ingeborg Atefi, Gilles F.H. Diercks, Artem Vorobyev, Janny Zuiderveen, Hillegonda J. Meijer, Hendri H. Pas, Detlef Zillikens, Enno Schmidt, Marcel F. Jonkman
- Re-examining mechanic's hands as a characteristic skin finding in dermatomyositis
- Josef Symon S. Concha, Joseph F. Merola, David Fiorentino, Victoria P. Werth
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?