Applied Bayesian Methods in the Rheumatic Diseases - 04/04/18

Doi : 10.1016/j.rdc.2018.01.003

Sindhu R. Johnson, MD, PhD ^a,^b,^c,^⁎ , George A. Tomlinson, PhD ^b,^d,^e, John T. Granton, MD ^f,^g, Gillian A. Hawker, MD, MSc ^b,^h, Brian M. Feldman, MD, MSc ^i,^j
^a Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital, 155 College Street, Toronto, Ontario M5T 3M6, Canada
^b Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
^c Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
^d Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada
^e Department of Medicine, Division of Support Systems and Outcomes, Toronto General Hospital Research Institute, University Health Network, Mount Sinai Hospital, Eaton North, 13th Floor, Room 238, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
^f Division of Respirology, Department of Medicine, Toronto General Hospital, University Health Network, MUNK Building, 11-1170, 200 Elizabeth Avenue, Toronto, Ontario M5G 2C4, Canada
^g Division of Critical Care Medicine, Department of Medicine, Toronto General Hospital, University Health Network, MUNK Building, 11-1170, 200 Elizabeth Avenue, Toronto, Ontario M5G 2C4, Canada
^h Division of Rheumatology, Department of Medicine, Women’s College Hospital, 76 Grenville Street, 8th Floor East, Room 815, Toronto, Ontario M5S 1B2, Canada
ⁱ Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
^j Division of Rheumatology, Department of Paediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada

^∗Corresponding author. Division of Rheumatology, Toronto Western Hospital, Ground Floor, East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.Division of RheumatologyToronto Western HospitalGround FloorEast Wing399 Bathurst StreetTorontoOntarioM5T 2S8Canada

Résumé

The use of applied Bayesian methods is increasing in rheumatology. Using the Bayes theorem, past evidence is updated with new data. Preexisting data are expressed as a prior probability distribution or prior. New observations are expressed as a likelihood. Through explicit incorporation of preexisting data and new data, this process informs how this new information should change the way we think. In this article, the authors highlight the use of applied Bayesian methods in the study of rheumatic diseases.

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Keywords : Bayesian, Statistics, Scleroderma, Systemic sclerosis, Juvenile inflammatory arthritis, Rheumatoid arthritis

Plan

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Introduction

Science and Statistical Inference

Bayesian Versus Frequentist Inference

Bayesian Inference in Rheumatology

Summary

	Disclosure Statement: None of the authors have any commercial or financial conflicts of interest to disclose.
	Dr S.R. Johnson has been awarded a Canadian Institutes of Health Research New Investigator Award. Dr G.A. Hawker is supported as the Sir John and Lady Eaton Chair of Medicine. Dr B.M. Feldman holds the Ho Family Chair in Autoimmune Diseases.

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Vol 44 - N° 2

P. 361-370 - mai 2018 Retour au numéro

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Cluster and Multiple Correspondence Analyses in Rheumatology : Paths to Uncovering Relationships in a Sea of Data
Lu Han, Susanne M. Benseler, Pascal N. Tyrrell

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Applied Bayesian Methods in the Rheumatic Diseases - 04/04/18

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