Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy—Antecedent Characteristics and Comorbidities - 25/04/18
, Seetha Shankaran, MD 2, Abbot Laptook, MD 3, Scott McDonald, BS 4, Martin Keszler, MD 3, Krisa Van Meurs, MD 5, Ronnie Guillet, MD, PhD 6, Sanjay Chawla, MD 2, Beena G. Sood, MD, MS 2, Sonia Bonifacio, MD 5, Abhik Das, PhD 7, Rosemary D. Higgins, MD 8Abstract |
Objective |
To determine the characteristics of term infants with persistent pulmonary hypertension of the newborn (PPHN) associated with moderate or severe hypoxic ischemic encephalopathy (HIE).
Methods |
We compared infants with and without PPHN enrolled in 2 randomized trials of therapeutic hypothermia: the induced hypothermia trial of cooling to 33.5°C for 72 hours vs normothermia, and the “usual-care” arm (33.5°C for 72 hours) of the optimizing cooling trial.
Results |
Among 303 infants with HIE from these 2 studies, 67 (22%) had PPHN and 236 (78%) did not. We compared infants with PPHN with those without PPHN. The proportion of patients treated with therapeutic hypothermia was similar in PPHN and no-PPHN groups (66% vs 65%). Medication use during resuscitation (58% vs 44%), acidosis after birth (pH: 7.0 ± 0.2 vs 7.1 ± 0.2), severe HIE (43% vs 28%), meconium aspiration syndrome (39% vs 7%), pulmonary hemorrhage (12% vs 3%), culture-positive sepsis (12% vs 3%), systemic hypotension (65% vs 28%), inhaled nitric oxide therapy (64% vs 3%), and extracorporeal membrane oxygenation (12% vs 0%) were more common in the PPHN group. Length of stay (26 ± 21 vs 16 ± 14 days) and mortality (27% vs 16%) were higher in the PPHN group.
Conclusions |
PPHN is common among infants with moderate/severe HIE and is associated with severe encephalopathy, lung disease, sepsis, systemic hypotension, and increased mortality. The prevalence of PPHN was not different between those infants receiving therapeutic hypothermia at 33.5°C in these 2 trials (44/197 = 22%) compared with infants receiving normothermia in the induced hypothermia trial (23/106 = 22%).
Le texte complet de cet article est disponible en PDF.Keywords : hypoxia, acidosis, asphyxia, cooling
Abbreviations : ECMO, HIE, IH, iNO, MAS, NICHD, OC, PPHN, PVR
Plan
| Supported by the National Institutes of Health (U10HD068263). The authors declare no conflicts of interest. |
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| Portions of this study were presented at the Pediatric Academic Societies annual meeting, May 6-9, 2017, San Francisco, California. |
Vol 196
P. 45 - mai 2018 Retour au numéro
Article précédent
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