Nanostructured lipid carriers for site-specific drug delivery - 29/05/18
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Graphical abstract |
Highlights |
• | Nanostructured lipid carriers (NLC) are modified solid lipid nanoparticles consisting of a blend of solid and liquid lipids. |
• | Overview of fabrication methods and characterization techniques. |
• | Explores potential as a delivery system through various routes of administration. |
Abstract |
Nanostructured lipid carriers (NLC), comprises of a blend of solid and liquid lipids which results in a partially crystallized lipid system and imparts many advantages over solid lipid nanoparticles such as enhanced drug loading capacity, drug release modulation flexibility and improved stability. NLC have found numerous applications in both pharmaceutical and cosmetic industry due to ease of preparation, the feasibility of scale-up, biocompatibility, non-toxicity, enhanced targeting efficiency and the possibility of site-specific delivery via various routes of administration. This review highlights the NLC with focus on the structure, the various fabrication techniques used and the characterization techniques which are critical in the development of a suitable and stable formulation. The review also provides an insight into the potential of NLC as site-specific delivery systems and the therapeutic applications explored via various routes of administration.
Le texte complet de cet article est disponible en PDF.Keywords : NLC, Lipids, Crystallinity, Topical, Pulmonary, Blood-brain barrier, Intranasal, Drug delivery
Plan
Vol 103
P. 598-613 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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