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“P” and “DP:” Examining Symptom-Level Bifactor Models of Psychopathology and Dysregulation in Clinically Referred Children and Adolescents - 31/05/18

Doi : 10.1016/j.jaac.2018.03.010 
John D. Haltigan, PhD a, b, c, , Madison Aitken, PhD a, Tracey Skilling, PhD a, b, Joanna Henderson, PhD a, b, Lisa Hawke, PhD a, Marco Battaglia, MD a, b, John Strauss, MD a, b, Peter Szatmari, MD a, b, c, Brendan F. Andrade, PhD a, b
a Centre for Addiction and Mental Health, Toronto, Ontario, Canada 
b University of Toronto, Ontario, Canada 
c Hospital for Sick Children, Toronto, Ontario, Canada 

Correspondence to John D. Haltigan, PhD, University of Toronto, Department of Psychiatry Centre for Addiction and Mental Health, Cundill Centre for Child and Youth Depression, Slaight Centre for Youth In Transition, 6225, 6th Floor, 80 Workman Way, Toronto, ON M6J 1H4, CanadaUniversity of TorontoDepartment of Psychiatry Centre for Addiction and Mental HealthCundill Centre for Child and Youth DepressionSlaight Centre for Youth In Transition6225, 6th Floor, 80 Workman WayTorontoON M6J 1H4Canada

Abstract

Objective

This study examined cross-informant evidence for a general factor of psychopathology (“P”) and a narrower, clinically oriented dysregulation general factor based on the Dysregulation Profile (“DP”) in a large clinical sample of children and adolescents. We also compared the magnitude of P and DP general factor associations with self-harm and suicidal ideation as an indicator of criterion validity.

Method

Itemwise data from the Child Behavior Checklist (N = 2,934; 4−18 years of age) were analyzed using confirmatory bifactor modeling and replicated in a supplementary analysis using Youth Self Report data (N = 2,395).

Results

General P and DP bifactor models fit the data better than single-factor and correlated factor models. Cross-informant criterion analyses on a subset of youth (n = 1,552) suggested that whether modeled as latent P or DP, associations with a brief composite index of self-harm and suicidal ideation are essentially of the same magnitude.

Conclusion

Our findings provide novel, large-sample support for the existence of general factors of psychopathology and dysregulation in clinically referred children and adolescents using a standardized rating system of psychopathology symptoms. Moreover, our results provide preliminary evidence that general psychopathology and dysregulation factors are clinically meaningful constructs. In addition, our findings raise the possibility that the DP general factor may serve as an efficient proxy for the general psychopathology factor in future clinical applications. Further efforts are necessary to understand the core empirical meaning of the P factor and to determine how it can be applied to clinical assessment and intervention.

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Key words : dysregulation, externalizing, internalizing, p-factor, psychopathology


Plan


 Dr. Haltigan served as the statistical expert for this research.
 Disclosure: Dr. Haltigan has received research support from the Social Sciences and Humanities Research Council of Canada, the Canadian Institutes of Health Research, and the University of Toronto. Dr. Aitken has received research support from the Centre for Addiction and Mental Health Foundation. Dr. Skilling has received research support from the Social Sciences and Humanities Research Council of Canada, the Canadian Institutes of Health Research, the University of Ottawa University Medical Research Fund, the University of Toronto, and the Slaight Family Child and Youth Mental Health Innovation Fund. Dr. Henderson has received research support from the Ontario SPOR SUPPORT Unit, Health Canada, the Canadian Institutes of Health Research, the Law Foundation of Ontario, Access to Justice Fund Grants Program, the Networks of Centres of Excellence International Knowledge Translation Platform, and the Ontario Ministry of Training for Colleges and Universities. Dr. Hawke has received research support from the Centre for Addiction and Mental Health Foundation and the Hospital for Sick Children Foundation. Dr. Battaglia has received research support from the Fonds de Recherche du Québec, the Social Sciences and Humanities Research Council of Canada, the Merck Sharp and Dome Foundation, the Quebec Pain Research Network, the Natural Sciences and Engineering Research Council of Canada, the Canadian Institutes of Health Research, and the Cundill Foundation. Dr. Strauss has received research support from the OCE Health Technologies Fund, the Canadian Institutes of Health Research, the Ontario Genomics Institute, and the Ministry of Research and Innovation. Dr. Szatmari has received support from Canadian Institutes of Health Research, the Ontario SPOR SUPPORT Unit, and the Jamie and Patsy Anderson Chair in Child and Youth Mental Health. He has received royalties from Guilford Press for his book A Mind Apart: Understanding Children with Autism and Asperger Syndrome. Dr. Andrade has received research support from the Canadian Institutes of Health Research, the University of Toronto, and the Hospital for Sick Children Medical Psychiatry Alliance.


© 2018  American Academy of Child and Adolescent Psychiatry. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 57 - N° 6

P. 384-396 - juin 2018 Retour au numéro
Article précédent Article précédent
  • Criterion Validity and Utility of the General Factor of Psychopathology in Childhood: Predictive Associations With Independently Measured Severe Adverse Mental Health Outcomes in Adolescence
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  • Development of Posterior Medial Frontal Cortex Function in Pediatric Obsessive-Compulsive Disorder
  • Kate Dimond Fitzgerald, Yanni Liu, Timothy D. Johnson, Jason S. Moser, Rachel Marsh, Gregory L. Hanna, Stephan F. Taylor

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