Development of Posterior Medial Frontal Cortex Function in Pediatric Obsessive-Compulsive Disorder - 31/05/18
, Yanni Liu, PhD a, Timothy D. Johnson, PhD a, Jason S. Moser, PhD b, Rachel Marsh, PhD c, Gregory L. Hanna, MD a, Stephan F. Taylor, MD aAbstract |
Objective |
Abnormal engagement of the posterior medial frontal cortex (pMFC) occurs during performance monitoring in obsessive-compulsive disorder (OCD), including in pediatric patients. Yet, the development of pMFC function in OCD-affected youth remains poorly understood.
Method |
A total of 69 patients with pediatric OCD and 72 healthy controls (HC), 8 to 19 years of age, were scanned during the Multisource Interference Task (MSIT). The effects of group, age, performance, and interactions on pMFC response to errors and interference were tested in the region of interest [ROI]) and whole-brain analyses. Secondary analyses considered bilateral anterior insula/frontal operculum (aI/fO), given the contribution of these regions with pMFC to a cingulo-opercular network (CON) for task control (e.g., error and interference processing).
Results |
Error-related pMFC activity was greater for OCD patients than for HC, increased with age in OCD patients, but decreased with age in HC. Greater pMFC activation associated with better performance in HC but not OCD patients. In the patients, greater pMFC activation to errors was associated with lower OCD severity. Altered error-related activation and performance associations were also observed in the right aI/fO in OCD patients, whereas the left aI/fO response to interference was associated with lower OCD severity.
Conclusion |
Atypical increase in error-related pMFC activation with age in pediatric OCD suggests altered development of pMFC function during the early course of illness. Greater pMFC activation with better performance in HC, and with age and lower symptom severity in OCD patients, suggests an adaptive function of heightened pMFC response to errors that could be further enhanced (e.g., via cognitive training) to improve outcomes in OCD from the early course of illness.
Le texte complet de cet article est disponible en PDF.Key words : pediatric obsessive-compulsive disorder, performance monitoring, task control, cingulo-opercular network, development
Plan
| This research was supported by National Institute of Mental Health grants K23-MH082176 (KDF) and R01-MH102242 (KDF/SFT), the Dana Foundation (KDF), NARSAD (KDF), and the Todd Ouida Memorial Children’s Fund (KDF). |
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| This study was presented in symposia at the American Academy of Child and Adolescent Psychiatry’s 63rd Annual Meeting in New York, NY, October 24-29, 2016; the American College of Neuropsychopharmacology’s 55th Annual Meeting in Hollywood, FL, December 4-8, 2016; and the Society of Biological Psychiatry’s 72nd Annual Meeting in San Diego, CA, May 18-20, 2017. |
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| Dr. Johnson served as the statistical expert for this research. |
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| Disclosure: Dr. Taylor has received research support through Otsuka/Vanguard Research Group and Boehringer-Ingelheim. Drs. Fitzgerald, Liu, Johnson, Moser, Marsh, and Hanna report no biomedical financial interests or potential conflicts of interest. |
Vol 57 - N° 6
P. 397-406 - juin 2018 Retour au numéro
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