Stem Cells for Urinary Incontinence: Functional Differentiation or Cytokine Effects? - 18/06/18

Abstract |
Minimally invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been under way, and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues or exert benefits through a transient presence and the secretion of regenerative factors. This review explores the fate of therapeutic stem cells for stress urinary incontinence and how this may relate to their mechanism of action.
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| Financial Disclosure:The authors declare that they have no relevant financial interests. |
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| Funding Support:This study was supported by theNational Institutes of Health(RO1 HD059859-05), theVeterans Affairs Rehabilitation Research and Development Merit Review(I01 RX000228), and theCleveland Clinic. |
Vol 117
P. 9-17 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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