Pruritus Associated with Targeted Anticancer Therapies and Their Management - 19/06/18

Doi : 10.1016/j.det.2018.02.010

Jennifer Wu, MD ^a,^b,^c,^d, Mario E. Lacouture, MD ^e,^f,^⁎
^a Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, Suite 407, Room 4312, New York, NY 10022, USA
^b Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, No.5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan
^c Department of Dermatology, Chang Gung Memorial Hospital, Taipei, No.199, Dunhua North Road, Zhongshan District, Taipei 105, Taiwan
^d College of Medicine, Chang Gung University, No.159, Wenhua 1st Road, Guishan District, Taoyuan City 333, Taiwan
^e Oncodermatology Program, Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Outpatient Center, 16 East 60th Street, Suite 407, Room 4312, New York, NY 10022, USA
^f Department of Medicine, Weill Cornell Medical College, 1320 York Avenue, New York, NY 10021, USA

^∗Corresponding author. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 60th Street Outpatient Center, 16 East 60th Street, Suite 407, Room 4312, New York, NY 10022.Dermatology ServiceDepartment of MedicineMemorial Sloan Kettering Cancer Center60th Street Outpatient Center16 East 60th StreetSuite 407Room 4312New YorkNY10022

Résumé

Targeted anticancer therapies have significantly increased the survival of patients with a variety of malignancies, improving tolerability and treatment duration. The increased lifespan and the expanded use of targeted agents have led to a variety of treatment-related adverse events. Pruritus, a common dermatologic adverse event with various incidences ranging from 2.2% to 47% across different categories of targeted anticancer therapies, has been overlooked. This article reviews the incidence, accompanying skin conditions, possible pathomechanism, and proposed management algorithms of pruritus associated with targeted therapies, including immunotherapies.

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Keywords : Pruritus, Itch, Targeted therapy, Immunotherapy, Cancer, Management