Interventional endoscopy and interventional radiology have led to the development of minimally invasive techniques for management of kidney and ureteral diseases in the dog and cat including idiopathic renal hematuria, ureteral obstruction, and ectopic ureters. Sclerotherapy is a renal-sparing chemical cauterization technique used in cases of idiopathic renal hematuria. Diagnosis of ureteral obstruction is challenging in some cases based on ultrasound alone and antegrade pyelography should be considered. Treatment options for obstructions include nephrostomy tubes, ureteral stents, and subcutaneous ureteral bypass devices. Treatment with cystoscopic-guided laser ablation provides similar outcomes to surgery in dogs with intramural ectopic ureters.