Long noncoding RNA HOXD-AS1 aggravates osteosarcoma carcinogenesis through epigenetically inhibiting p57 via EZH2 - 25/08/18
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Graphical abstract |
Highlights |
• | HOXD-AS1 expression level is significantly up-regulated in osteosarcoma tissue and cells, which indicates poor prognosis. |
• | HOXD-AS1 silencing inhibited the osteosarcoma cells proliferation and induced G1/G0 phase arrest, and repressed tumor growth. |
• | HOXD-AS1 epigenetically repressed p57 through recruiting EZH2 to the promoter of p57. |
Abstract |
Osteosarcoma is the most common primary malignant bone tumor and long non-coding RNAs (lncRNAs) have been proved to epigenetically regulate the oncogenesis of osteosarcoma. In this research, we investigate the role of lncRNA HOXD-AS1 on the osteosarcoma oncogenesis. Results revealed that HOXD-AS1 expression level was significantly up-regulated in osteosarcoma tissue and cells, moreover, the aberrant overexpression predicted the poor prognosis of osteosarcoma patients. Loss-of-functional experiments indicated that HOXD-AS1 silencing inhibited the osteosarcoma cells proliferation and induced G1/G0 phase arrest in vitro, and repressed tumor cell growth in vivo. Mechanistic investigations showed that HOXD-AS1 epigenetically repressed p57 through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p57. Rescue experiments revealed that p57 could recover the oncogenic role of HOXD-AS1 on osteosarcoma. In conclusion, our study confirmed that HOXD-AS1 could interact with EZH2, and then repress p57 expression, to aggravate osteosarcoma oncogenesis. which provide new idea for the osteosarcoma tumorigenesis.
Le texte complet de cet article est disponible en PDF.Keywords : Osteosarcoma, HOXD-AS1, lncRNA, p57, EZH2
Plan
Vol 106
P. 890-895 - octobre 2018 Retour au numéro
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