Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function.

To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers.

Cross-sectional study on 7753 participants, 20–80 years of age, in the National Health and Nutrition Examination Survey. Gender-based tertiles for CRP, blood eosinophils, and blood neutrophils were analysed in relation to the following lung function parameters: forced expiratory volume in 1 s (FEV₁% predicted), forced vital capacity (FVC % predicted), and FEV₁/FVC ratio.

CRP, blood eosinophils, and blood neutrophils levels were inversely related to FEV₁ and FVC. Only blood eosinophils and blood neutrophils were inversely related to FEV₁/FVC ratio. Further, lower lung function was found with increased number of elevated inflammatory markers in the highest tertile (one, two or three vs. non elevated) for FEV₁ (β-coeff., −2.20, −4.43, and −6.43, p < 0.001) and FVC (β-coeff., −1.70, −3.15 and −5.33, p < 0.001), respectively.

CRP, blood eosinophils, and blood neutrophils offer independent and additive information in relation to lower FEV₁ and FVC in the general population. This indicates that a combination of biomarkers yields more information than the biomarkers assessed individually.