Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video) - 10/10/18
Abstract |
Background and Aims |
Patients with many different digestive diseases undergo repeated EGDs throughout their lives. Tethered capsule endomicroscopy (TCE) is a less-invasive method for obtaining high-resolution images of the GI mucosa for diagnosis and treatment planning of GI tract diseases. In this article, we present our results from a single-center study aimed at testing the safety and feasibility of TCE for imaging the esophagus, stomach, and duodenum.
Methods |
After being swallowed by a participant without sedation, the tethered capsule obtains cross-sectional, 10 μm–resolution, optical coherence tomography images as the device traverses the alimentary tract. After imaging, the device is withdrawn through the mouth, disinfected, and reused. Safety and feasibility of TCE were tested, focusing on imaging the esophagus of healthy volunteers and patients with Barrett’s esophagus (BE) and the duodenum of healthy volunteers. Images were compared with endoscopy and histopathology findings when available.
Results |
Thirty-eight patients were enrolled. No adverse effects were reported. The TCE device swallowing rate was 34 of 38 (89%). The appearance of a physiologic upper GI wall, including its microscopic pathology, was visualized with a tissue coverage of 85.4% ± 14.9% and 90.3% ± 6.8% in the esophagus of BE patients with and without endoscopic evidence of a hiatal hernia, respectively, as well as 84.8% ± 7.4% in the duodenum. A blinded comparison of TCE and endoscopic BE measurements showed a strong to very strong correlation (r = 0.7-0.83; P < .05) for circumferential extent and a strong correlation (r = 0.77-0.78; P < .01) for maximum extent (Prague classification). TCE interobserver correlation was very strong, at r = 0.92 and r = 0.84 (P < .01), for Prague classification circumferential (C) and maximal (M) length measurements, respectively.
Conclusions |
TCE is a safe and feasible procedure for obtaining high-resolution microscopic images of the upper GI tract without endoscopic assistance or sedation.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Abbreviations : BE, MGH, OCT, TCE
Plan
| DISCLOSURE: This work was supported in part by U.S. National Institutes of Health grants NIH R01CA103769 (G.J.T.) and 1 R01 DK100569-01A1 (G.J.T.). John and Dottie Remondi (G.J.T.) and the MGH Research Scholars program (G.J.T.) provided funding (G.J.T.). L. Quénéhervé received funding from the DHU2020, the DHU Oncogreffe, and the SantéDige Foundation. M. Gora, J. Sauk, N. Nishioka, and G. Tearney, have the rights to receive royalties as part of a licensing arrangement between NinePoint Medical and Massachusetts General Hospital. G. Tearney is a consultant for NinePoint Medical and receives sponsored research from iLumen and Boston Scientific. All other authors disclosed no financial relationships relevant to this article. |
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| If you would like to chat with an author of this article, you may contact Dr Tearney at gtearney@partners.org. |
Vol 88 - N° 5
P. 830 - novembre 2018 Retour au numéro
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