Mastitis is a prevalent and costly disease on dairy farms. Improved management and hygiene can reduce the risk of infection by contagious or environmental pathogens, and genetic selection can confer permanent improvement in mastitis resistance. National veterinary recording systems in the Nordic countries have allowed direct selection for sire families with low incidence of clinical mastitis for 3 decades, whereas other countries have practiced indirect selection for lower somatic cell count. Recently, pooling of producer-recorded data from on-farm herd management software programs has enabled selection for reduced incidence of clinical mastitis in the United States and other leading dairy countries.