Neutrophilic dermatoses : Pyoderma gangrenosum and other bowel- and arthritis-associated neutrophilic dermatoses - 10/11/18
Abstract |
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes. While some neutrophilic dermatoses may resolve spontaneously, most require treatment to achieve remission. Delays in diagnosis and treatment can lead to significant patient morbidity and even mortality. Therapeutic modalities range from systemic corticosteroids to novel biologic agents, and the treatment literature is rapidly expanding. The second article in this continuing medical education series reviews the epidemiology, clinical characteristics, histopathologic features, diagnosis, and management of pyoderma gangrenosum as well as bowel-associated dermatosis-arthritis syndrome and the arthritis-associated neutrophilic dermatoses rheumatoid neutrophilic dermatitis and adult Still disease.
Le texte complet de cet article est disponible en PDF.Key words : adult Still disease, bowel-associated dermatosis-arthritis syndrome, neutrophil, neutrophilic dermatosis, pyoderma gangrenosum, rheumatoid neutrophilic dermatitis
Abbreviations used : ASD, BADAS, IBD, IL, ND, PG, RF, RND, TNF
Plan
Date of release: December 2018 |
|
Expiration date: December 2021 |
|
Supported by a private donation from Mr Jerry and Mrs Joan Berstein. |
|
Conflicts of interest: None disclosed. |
Vol 79 - N° 6
P. 1009-1022 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?