Paget's disease of bone - 19/11/18
Doi : 10.1016/j.beem.2018.05.005
Natasha M. Appelman-Dijkstra, MD, PhD 
: Associate Professor of Medicine, Socrates E. Papapoulos, MD, PhD ⁎ : Professor of Medicine
: Associate Professor of Medicine, Socrates E. Papapoulos, MD, PhD ⁎ : Professor of Medicine Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands
∗Corresponding author. Center for Bone Quality, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Fax: +31 71 524 8136.Center for Bone QualityLeiden University Medical CenterAlbinusdreef 2Leiden2333 ZAThe Netherlands
Abstract |
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood.
Le texte complet de cet article est disponible en PDF.Keywords : bone turnover, genetics, Paget's disease, SQSTM1, zoledronate
Plan
© 2018
Elsevier Ltd. Tous droits réservés.
Vol 32 - N° 5
P. 657-668 - octobre 2018 Retour au numéro
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