Early-Onset Inflammatory Bowel Disease - 21/11/18
Résumé |
The epidemiology of inflammatory bowel disease has changed over the past 4 decades. The incidence is rising dramatically and the age of onset has become younger. This changing landscape of inflammatory bowel disease reflects the new recognition that the youngest children with inflammatory bowel disease are enriched in cases with underlying primary immunodeficiency and monogenic causes. The management of these cases can be quite different, with specific genetic etiologies supporting unique interventions and some requiring hematopoietic cell transplantation for effective treatment.
Le texte complet de cet article est disponible en PDF.Keywords : VEO-IBD, Primary immunodeficiencies, Inflammation, Monogenic
Plan
| Disclosure Statement: The authors would like to acknowledge support from The Children's Hospital of Philadelphia, the Wallace Chair of Pediatrics, and K23 DK100461. |
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| The US Immunodeficiency Network (USIDNET) data were supplied by the following contributors who provided at least 1% of the data for analysis: Ramsay Fuleihan, Elizabeth Garabedian, Charlotte Cunningham-Rundles, Rebecca Marsh, Hans D. Ochs, Avni Joshi, Daniel Suez, Elizabeth A. Secord, John Routes, Javeed Akhter, Francisco A. Bonilla, Jennifer Puck, Niraj Patel, Rebecca Buckley, Patricia Lugar, Burcin Uygungil, Gary Kleiner, and Morton J. Cowan. |
Vol 39 - N° 1
P. 63-79 - février 2019 Retour au numéro
Article précédent
- An Update on Syndromes with a Hyper-IgE Phenotype
- Jenna R.E. Bergerson, Alexandra F. Freeman
- Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders
- Shradha Agarwal, Charlotte Cunningham-Rundles
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