Neurological irAE are very uncommon in cancer patients with ICIs treatment, in less than 3% of the patients, but with potentially poor outcome.
ICI-associated myositis with or without myasthenia gravis are the more frequent complications and respond well to corticosteroid therapy and ICIs discontinuation.
Oculobulbar involvement is unique and common among patients with ICI-associated myositis.
Myocarditis is occasionally associated in irMyositis and consists with diaphragm disorder pejoratives prognostic factors.
Immune checkpoint inhibitors have been increasingly used in patients with various cancers. Despite favourable oncological outcomes these treatments have also been associated with immune-related adverse events. Neurological irAE are rare but potentially severe and neuromuscular complications are the most common. This is a new group of neurologic complications of systemic anticancer therapies, often responsive to immune-modulating therapies. Early recognition and treatment are crucial for timely improvement of functional outcome and requires a multidisciplinary approach.Le texte complet de cet article est disponible en PDF.